This is the first comprehensive, accurate introductory text on hematology for medical students. The many topics of hematology are covered and each chapter begins with an overview and then proceeds to an outline of key concepts for each specialty area. The text includes simple line drawings, algorithms and color plates, and features bulleted points and bolded key words. With its depth, and concise format, this book serves as a thorough text, general reference, and a review for the USMLE Step 1 exam, and is a valuable tool for the internal medicine clerkship rotation and exam. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
It is less than 80 years since John Newport Langley first proposed the role of "receptive substances" as the site of drug action from his obser vations on the effects of nicotine and curare at the myoneural junction. The many advances in our understanding of receptor biology that have occurred during the intervening period mirror the extraordinary growth of knowledge in the biological sciences and in cell and molecular biology in particular. Receptor biology, in common with many other topics in contemporary biology, is on the threshold of a transition from being a descriptive, phenomenological discipline to one in which underlying mechanisms and regulatory principles can be defined with incr...
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by non-specific inflammation that can afflict virtually any organ in the body. Patients with severe lupus are more likely to survive now than they were 30 years ago, but the morbidity from disease and treatment is still significant. Consequently, there is significant interest in developing new agents to treat SLE that have greater efficacy and fewer side effects. As part of efforts to identify novel cytotoxic agents, a library of 1,4-benzodiazepines was screened for lymphotoxic members, leading to the identification of the cytotoxic benzodiazepine, Bz-423. Bz-423 ameliorated disease in two lupus models of mice by killing specific subpopulations of disease-causing lymphocytes without adverse toxicities or global immunosuppression. The mechanism of Bz-423-induced cell death was found to be critically dependent on an early superoxide (O 2-) signal.
Regulation of cell motility and actin polymerization in neuroblastoma cells by insulin-like growth factor I.